Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency

HGH Growth Hormone Medical Studies - Endocrine Care and Human Growth Hormone @ www.HGHnews.us

Endocrine Care – HGH, The Human Growth Hormone

Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial

Adult GH Deficiency (AGHD) is characterized by an altered body composition, an atherogenic lipid profile, decreased exercise capacity, and diminished quality of life. We performed a randomized, double-blind, placebo-controlled, multicenter study in 166 subjects with AGHD to assess the effects of GH on these outcomes. GH was initiated at 0.0125 mg/kg·d, increased to 0.025 mg/kg·d as tolerated, or decreased to 0.00625 mg/kg·d for 12 months. Primary measures of efficacy included body composition, strength and endurance, and quality of life. Additional parameters included serum IGF-I concentrations, serum lipids, and bone mineral density.

After 12 months, 79% of subjects remained on GH 0.0125 mg/kg·d, whereas 21% received 0.00625 mg/kg·d. GH-treated men and women demonstrated significant decreases in total body and trunk fat and increases in lean body mass over baseline. In GH-treated men, mean IGF-I sd scores exceeded age-adjusted normal ranges, whereas similar doses produced a smaller response in women. GH treatment was associated with significant improvements in total cholesterol and low-density lipoprotein (P < 0.05 for all). No significant treatment effects were observed in strength and endurance, quality of life, or bone mineral density. GH treatment was generally well tolerated. Subjects with AGHD should receive individualized GH therapy to maintain IGF-I between the mean value and +2 sd and improve body composition and cardiovascular risk factors.

GH IS REQUIRED for normal growth and metabolic homeostasis in children. However, GH secretion occurs throughout life and is known to have profound effects on anabolism, lipolysis, and carbohydrate metabolism. Individuals who develop adult GH deficiency (AGHD) secondary to pituitary or hypothalamic disease exhibit abnormal body composition, characterized by a significant increase in fat mass, particularly visceral fat, and a decrease in lean body mass (1, 2, 3, 4, 5, 6). Many have diminished strength and exercise capacity that may improve with GH therapy (7, 8). Adults with AGHD also demonstrate altered lipid metabolism, increased incidence of cardiovascular disease, and diminished quality of life (9, 10, 11, 12). Reduced life expectancy secondary to increased cerebrovascular and cardiovascular disease has also been reported in patients with hypopituitarism (13). Adults with AGHD experience feelings of social isolation, decreased energy, and an overall poorer quality of life when compared with controls (11, 14, 15, 16). Bone mineral density (BMD) is also reduced in these subjects (6), resulting in a 3-fold increase in bone fracture rate (17).

Short-term GH replacement therapy in adults has been associated with beneficial effects on body composition, fat distribution, and quality of life (2, 18, 19). Improvements in bone mineral content and BMD are not apparent until GH has been administered for at least 18 months (20, 21). In general, studies of GH therapy in subjects with AGHD have been relatively small, nonrandomized, or uncontrolled. Moreover, potential differences in the ability of men and women to respond to GH have not been adequately examined in most of these studies.

This large multicenter, randomized, placebo-controlled study explored the effects of GH treatment on body composition and physical performance. The primary end points were a decrease in percentage of body fat, an increase in muscle strength, and improved quality of life. The anticipated reduction in cardiovascular risk emerged as the most compelling reason to examine the impact of GH replacement therapy in adults with GHD.

If you think you may benefit from Human Growth Hormone Treatment and want to learn more about HGH, click here for more detailed hormone information. Bio-Identical hormone treatments are considered healthiest and many naturopath, age management and anti-aging medical physicians prescribe HGH injections for patients who need it to balance and restore their hormones.

Men have a particularly difficult time finding physicians and information regarding male hormone related therapy as the medical community tends to shy away from supporting bio-identical treatments and therapies for men. However, times are changing and many general practitioners now contemplate the advantagous, benefits as well as effects and risks inherent in hormone replacement therapy for men. Click here for a good resource for HGH Therapy for Men to read more…

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Anti-Aging Therapeutics, Hormone Replacement Therapies, HGH, Aging and World Health Org

Anti-Aging Therapeutics Seminars, HGH and Hormone Replacement Therapy Information, Biomarkers for Aging

The evening workshop entitled Anti-Aging Therapeutics: The Anti-Aging Triad will take place in Orlando, Florida, April 8 at 6:30pm all attendees and vendors are welcome to attend. It is my intention to address modern concepts in anti-aging therapeutics, with a specific focus on what I have termed the Anti-Aging Triad of telomeres, stem cells and calorie restriction.

The Anti-Aging Triad is the title of my new book which will be launched at the April meeting and is available on an international basis. In the evening symposium I shall invite guest comments and short presentations. This will give a balanced perspective. It is my intention to express opinions on the real future of anti-aging medicine which is becoming increasingly evidence-based. Anti-aging medicine seeks evidence-based proposals to promote longevity. I propose “a triad” of interventions that are key targets in the future of anti-aging medicine. These proposals will ultimately supersede current “band aid” anti-aging initiatives such as hormone replacement therapies or standard esthetic interventions.

In the last two decades there has been expanding scientific research on the importance of telomere shortening as a biomarker of aging; and a confirmation of the role of calorie restriction in the enhancement of average and maximum lifespan. Stem cell sciences are emerging with promise for the management of chronic disease, new methods for organ production and specific actions on longevity promotion.


Hormone Replacement Therapies – HGH – The Human Growth Hormone

HGH and Hormone Replacement Therapy with bio-identical hormones is a very important treatment program that can also promote optimal health and wellness in those men and women experiencing symptoms due to menopause in women and andropause hypogonadism (male menopause) in men. Bio-identical (BHRT) – hormone replacement therapy for men and women has become a very effective tool in the fight against low hormonal health symptoms and conditions caused by menopause and hypogonadism, the male menopause. A hormone treatment program that replaces low testosterone levels and low human growth hormone levels can have a positive impact on a person’s health and quality of life. HGH and Testosterone Clinics with physicians that are hormone specialists can prescribe hormone injections and HGH replacement injections as part of the hormone therapy program. For more information on the benefits of HGH Therapy, HGH Injections  and Human Growth Hormone Programs visit AAG Health Medical Clinic in Miami Florida. HGH Therapy: Human Growth Hormone Therapy Programs at AAG Health – Bioidentical HGH Treatment Therapies – www.aaghealth.com

Learn about HGH Therapies, HGH Clinics that offer Bio-Identical Human Growth Hormone and Somatropin rHGH Injectable Growth Hormone for male hormone replacement therapy and female menopause bio-identical hormone replacement HGH Clinic @ www.hghtherapy.com


Hormone Replacement for Men: Pros, Cons

Testosterone Hormone Replacement & HGH Injections


Testosterone Replacement May Lower Risk of Heart Disease, Diabetes, Death, but Long-Term Effects Unclear

By Kathleen Doheny
WebMD Health News Reviewed by Louise Chang, MD

June 18, 2008 — Testosterone replacement therapy can help older men deficient in the hormone reduce their risks of heart disease, diabetes, and death, according to new research presented this week at ENDO 08, the annual meeting of The Endocrine Society.

”The goal of testosterone treatment is to keep the levels within normal range,” says Farid Saad, director of scientific affairs for Bayer Schering Pharma in Berlin. Saad presented two of the studies at the meeting, held in San Francisco. Bayer Schering Pharma makes several testosterone products.

Low levels of testosterone are common with age, Saad says, occurring in about 18% of 70-year-olds. Low levels of testosterone, he says, are associated with the metabolic syndrome — a cluster of risk factors such as abnormal cholesterol and high blood pressure that boost risk of heart disease, stroke, and type 2 diabetes as well as other risks to health.

In the studies, Saad and his colleagues found that testosterone replacement therapy reduced the metabolic syndrome risk factors and did so in a similar way in all the age ranges studied.

Testosterone Replacement Therapy and Heart Disease Risks

In the first study, Saad’s team looked at 95 men, aged 34 to 69, with low levels of testosterone.

All had metabolic syndrome. Those who have this diagnosis must have three of five risk factors: increased waist circumference, low “good” cholesterol or HDL, high triglycerides, elevated blood pressure, and elevated blood sugar.

“We treated them for at least a year,” he tells WebMD. Every three months, they measured cholesterol, waist circumference, and other parameters.

The testosterone replacement was given as a long-acting injection, every three months. The same product is not yet available in the U.S., Saad says, although other types are.

Testosterone Replacement Therapy: Test Results

“We saw a consistent improvement of the parameters of metabolic syndrome,” Saad says. The men were not given a special diet or exercise program.

The supplemental testosterone reduced total cholesterol, “bad” LDL cholesterol, triglycerides, and body mass index while improving “good” HDL cholesterol. The men lost their pot bellies, Saad says. “What we see after 12 months is a reduction in two or three trouser sizes, three or four inches off the waist. We see a reduction by one-fourth to one-third of their total cholesterol.”

No adverse effects were reported, he says.

While hormone replacement therapy for women has been found to be associated with increased risks of heart disease and other problems, Saad doesn’t foresee that will be the case with testosterone replacement. “There are fundamental differences between hormone replacement in women and testosterone treatment in men,” he tells WebMD.

Testosterone Replacement Therapy: No Age Effects?

In a second study, Saad divided the same 95 men into three groups, based on age: less than 57, 57 to 63, and older than 63.

They found the older men and the younger men had similar improvement in their risk factors.

“There are some precautions with testosterone supplementation,” Saad tells WebMD. “We need to monitor the prostate.”

“It is well known that with prostate cancer, the cancer is usually dependent on testosterone. Prostate cancer is a slow-growing tumor.” Cancer of the gland must be ruled out before starting supplements, he says. He also advises routine prostate checkups while on treatment.

A test to monitor red blood cell formation, called a hematocrit, is needed, too. “Testosterone increases red blood cells,” he says. In excess, it can theoretically boost heart attack or stroke risk.

Testosterone and Death Risk

Low testosterone levels are associated with an increased risk of death, according to Robin Haring, a researcher from the Institute for Community Medicine at Ernst-Moritz-Arndt University in Griefswald, Germany, who presented the finding at the meeting.

He evaluated data on nearly 2,000 men, aged 20 to 79, who participated in the Study of Health in Pomerania, following them for seven years until August 2007. He noted testosterone levels, age, weight, smoking habits, and physical activity. The drugmaker Novo Nordisk partly funded the study.

During the follow-up, 226 men died. “Men with low testosterone have a more than twofold higher risk of death during the follow-up period,” he says.

They were more likely to die of cardiovascular disease and cancer, but not of other causes.

Testosterone Replacement Therapy: Long-Term Effects Unknown

Another researcher, Jane F. Reckelhoff, PhD, professor of physiology and biophysics at the University of Mississippi Medical Center in Jackson, offers a caveat about supplemental testosterone: “We don’t know what the long-terms effects are. The safety studies have not been done and they need to be done.”

She reviewed the studies for WebMD and has published on a review about testosterone supplements for the American Journal of Physiology Renal Physiology.

Her chief concerns: “Testosterone [in excess] can increase blood pressure and compromise kidney function.”

But an advocate of testosterone replacement therapy, Martin Miner, MD, co-director of the Men’s Health Center at the Miriam Hospital of Brown University in Providence, R.I., says the studies show that restoring testosterone when it is low improves metabolic syndrome factors and could help prevent type 2 diabetes and cardiovascular risks.

He agrees close monitoring of men on testosterone is needed. “Checking hematocrit, PSA (prostate-specific antigen), and lower urinary tract symptoms in men is vital to the management of testosterone replacement therapy,” he says

To learn more about Testosterone Replacement Therapy: Testosterone Replacement Therapy or Testosterone Replacement Therapy for Men

Visit a hormone clinic to learn about HRT Hormone Replacement Therapy and the many hormone physicians centers available: Hormone Clinic: HGH Hormone Treatment and Testosterone Replacement Therapy @ AAG Health Hormone Physician’s Center – www.aaghealth.com or Testosterone Replacement Therapy for Men

To learn more about HGH Growth Hormone Replacement Therapy: HGH: Growth Hormone Replacement Therapy @ HGHTherapy.com, HGH Hormone Clinic @ AAGHealth.com or HGH Injection @ HGHTherapy.com