Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency

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Endocrine Care – HGH, The Human Growth Hormone

Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial

Adult GH Deficiency (AGHD) is characterized by an altered body composition, an atherogenic lipid profile, decreased exercise capacity, and diminished quality of life. We performed a randomized, double-blind, placebo-controlled, multicenter study in 166 subjects with AGHD to assess the effects of GH on these outcomes. GH was initiated at 0.0125 mg/kg·d, increased to 0.025 mg/kg·d as tolerated, or decreased to 0.00625 mg/kg·d for 12 months. Primary measures of efficacy included body composition, strength and endurance, and quality of life. Additional parameters included serum IGF-I concentrations, serum lipids, and bone mineral density.

After 12 months, 79% of subjects remained on GH 0.0125 mg/kg·d, whereas 21% received 0.00625 mg/kg·d. GH-treated men and women demonstrated significant decreases in total body and trunk fat and increases in lean body mass over baseline. In GH-treated men, mean IGF-I sd scores exceeded age-adjusted normal ranges, whereas similar doses produced a smaller response in women. GH treatment was associated with significant improvements in total cholesterol and low-density lipoprotein (P < 0.05 for all). No significant treatment effects were observed in strength and endurance, quality of life, or bone mineral density. GH treatment was generally well tolerated. Subjects with AGHD should receive individualized GH therapy to maintain IGF-I between the mean value and +2 sd and improve body composition and cardiovascular risk factors.

GH IS REQUIRED for normal growth and metabolic homeostasis in children. However, GH secretion occurs throughout life and is known to have profound effects on anabolism, lipolysis, and carbohydrate metabolism. Individuals who develop adult GH deficiency (AGHD) secondary to pituitary or hypothalamic disease exhibit abnormal body composition, characterized by a significant increase in fat mass, particularly visceral fat, and a decrease in lean body mass (1, 2, 3, 4, 5, 6). Many have diminished strength and exercise capacity that may improve with GH therapy (7, 8). Adults with AGHD also demonstrate altered lipid metabolism, increased incidence of cardiovascular disease, and diminished quality of life (9, 10, 11, 12). Reduced life expectancy secondary to increased cerebrovascular and cardiovascular disease has also been reported in patients with hypopituitarism (13). Adults with AGHD experience feelings of social isolation, decreased energy, and an overall poorer quality of life when compared with controls (11, 14, 15, 16). Bone mineral density (BMD) is also reduced in these subjects (6), resulting in a 3-fold increase in bone fracture rate (17).

Short-term GH replacement therapy in adults has been associated with beneficial effects on body composition, fat distribution, and quality of life (2, 18, 19). Improvements in bone mineral content and BMD are not apparent until GH has been administered for at least 18 months (20, 21). In general, studies of GH therapy in subjects with AGHD have been relatively small, nonrandomized, or uncontrolled. Moreover, potential differences in the ability of men and women to respond to GH have not been adequately examined in most of these studies.

This large multicenter, randomized, placebo-controlled study explored the effects of GH treatment on body composition and physical performance. The primary end points were a decrease in percentage of body fat, an increase in muscle strength, and improved quality of life. The anticipated reduction in cardiovascular risk emerged as the most compelling reason to examine the impact of GH replacement therapy in adults with GHD.

If you think you may benefit from Human Growth Hormone Treatment and want to learn more about HGH, click here for more detailed hormone information. Bio-Identical hormone treatments are considered healthiest and many naturopath, age management and anti-aging medical physicians prescribe HGH injections for patients who need it to balance and restore their hormones.

Men have a particularly difficult time finding physicians and information regarding male hormone related therapy as the medical community tends to shy away from supporting bio-identical treatments and therapies for men. However, times are changing and many general practitioners now contemplate the advantagous, benefits as well as effects and risks inherent in hormone replacement therapy for men. Click here for a good resource for HGH Therapy for Men to read more…

For a great amount of information specifically on HGH Therapy, growth hormone types, doctors and clinics the HGHTherapy.com site is a good treatment reference.

HGH and Obesity

HGH and Obesity

The risk of death from all causes, including cardiovascular disease and cancer, increases with rising obesity in both men and women in all age groups, and the risk associated with a high BMI is greater for whites than for blacks (Calle et al 1999).

Obesity increases the risk of developing metabolic syndrome and coronary heart disease (Shirai 2004); type 2 diabetes (Mensah et al 2004); osteoarthritis of major load-bearing joints, such as the knee (Felson et al 1997); hypertension (high blood pressure); sleep apnea (periods of suspended breathing during sleep) (Wolk et al 2003); and gall bladder disease (Petroni 2000).
The International Agency for Research on Cancer has classified obesity as a critical causal risk factor for cancers of the colon, breast (postmenopausal women), endometrium, kidney (renal cell), and esophagus (adenocarcinoma) (Calle et al 2004).

A study reported in the Journal of the American Medical Association suggests that obesity causes 111,909 deaths annually (Flegal et al 2005), while epidemiological evidence shows that a lower body weight is associated with lower mortality risk (Stevens 2000). In the well-known Framingham Heart Study, risk of death increased by 1 percent for each extra pound (0.45 kg) of weight between age 30 and 42 and increased by 2 percent between age 50 and 62 (Solomon et al 1997; Kopelman 2000).

Essential fatty acids (omega-3) found in fish oils promote thermogenesis, the process by which foods are converted to heat. Because of this, the body burns calories instead of converting them into fat for storage (McCarty 1994). Another benefit of essential fatty acids is to make cell membranes more sensitive to the effects of insulin (Storlien et al 1986, 1987, 1996; Borkman et al 1993; Vessby et al 1994; Pan et al 1995). Continue Reading

HGH – the Human Growth Hormone helps with Weight Control and Fatty Tissue

Hormone replacement with Human Growth Hormone can help with metabolism and fat loss. HGH treatment for symptoms due to menopause or andropause makes fat loss and increasing lean muscle mass easier to accomplish when growth hormone levels are raised to more youthful levels.

HGH is a natural substance that is excreted by the pituitary glands in the human body and bio-identical hormone treatments naturally restore lost growth hormone from your body. As we age, the level of HGH our bodies produces decreases over time and loss of lean muscle, weight gain and fatty tissue increase. Human growth hormone medications drugs usually given in the form of injections helps to raise the levels of HGH closer to optimal levels aiding in metabolism, the ability to exercise and subsequent fat loss.

Human growth hormone works by increasing the amount of IGF-1 that your liver excretes. IGF-1 blocks insulin from transporting glucose to your body cells. After eating, the pancreas usually releases insulin in sufficient levels to convert carbohydrates into glucose. The body stores the glucose in fat cells to use for energy as needed. As HGH induced IGF-1 prevents excess insulin from transporting glucose to be stored, the body starts to burn more fat for energy.

HGH helps control weight gain and with fat loss as follows: Normally, we use the glucose our body stores for energy and only when that stored glucose is used up do we use the fat reserves. By blocking the use of glucose stores, the theory is that we can get significant fat loss.

Here of some HGH Facts regarding weight loss and HGH Therapy:

You lose weight during your active periods. Energy is used for all aspects of living.

HGH helps with metabolism it does not force your body to burn fat.

HGH works well with a low-carb healthy diet and nutritional foods to lose unwanted weight.

HGH, in addition to helping you lose weight can help you increase muscle density and develop definition.

Human growth hormone increases strength, energy, stamina and endurance allowing better recovery after exercise.

HGH Hormone Replacement Therapies – HGH Testosterone – The Human Growth Hormone – Bio-Identical Hormones – Injectable HGH

HGH – Human Growth Hormone, Testosterone and Bio-Identical Hormone Replacement Therapy with “bio-identical” natural hormones is an important medical treatment program that can also promote optimal health and wellness in those men and women experiencing symptoms due to menopause in women and andropause – male menopause in men. Bio-identical (BHRT) – hormone replacement therapy for men and women has become a very effective tool in age management, and the fight against low hormonal health symptoms and deficiency conditions caused by menopause and hypogonadism, the male form of menopause.

A hormone treatment program including human growth hormone injections, testosterone injections, testosterone gel or creams that replace low testosterone levels and bio-identical HGH injections that increase and raise low human growth hormone levels can have a positive impact on a person’s health, weight and quality of life. HGH and Testosterone Clinics with physicians that are hormone specialists can prescribe hormone injections and HGH hormone replacement injections as part of a bio-identical hormone therapy program. For more information on the benefits of HGH Therapy, HGH Injections and Human Growth Hormone Programs visit AAG Health Medical Clinic in Miami Florida. Human Growth Hormone Therapy Programs at AAG Health – Bioidentical HGH Treatment Therapies – www.aaghealth.com

Some benefits of Human Growth Hormone HGH

* Positive changes in body composition including obesity.
* Restore lost of sex drive, treat impotence or low libido.
* Promote healthy lipids and cholesterol in the blood.
* Improved muscle strength, mass and tone.
* Improved bone composition and healing.
* Increased energy and exercise capacity.
* Cardiovascular and immuno health.
* Psychological well-being and mood.

Learn about HGH Therapies, HGH Clinics that offer Bio-Identical Human Growth Hormone and Somatropin rHGH Injectable Growth Hormone for male hormone replacement therapy and female menopause bio-identical hormone replacement HGH Clinic @ www.hghtherapy.com and HGH

HGH Therapy – AAG Health is one of the Best HGH Clinic visit the Growth Hormone Doctor at www.aaghealth.com | HGH @ http://www.aaghealth.com HGH Therapy at AAG Health – www.aaghealth.com

A Plus Side for Human Growth Hormone

By JANE E. BRODY
Published: May 3, 2010

Human Growth Hormone has acquired a bad reputation, thanks to athletes who have abused it in their quest for stardom. But for tens of thousands of children whose growth and development are stymied by a deficiency of growth hormone, daily injections of this biologically synthesized growth stimulant can put them on track toward normality.

I’m not talking about children with normal hormone levels whose genetic heritage will keep them well below the average height for American men and women (respectively, 5 feet 9 inches and just under 5 feet 4), although they, too, can sometimes benefit from an artificial boost from the hormone.

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