Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency

HGH Growth Hormone Medical Studies - Endocrine Care and Human Growth Hormone @ www.HGHnews.us

Endocrine Care – HGH, The Human Growth Hormone

Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial

Adult GH Deficiency (AGHD) is characterized by an altered body composition, an atherogenic lipid profile, decreased exercise capacity, and diminished quality of life. We performed a randomized, double-blind, placebo-controlled, multicenter study in 166 subjects with AGHD to assess the effects of GH on these outcomes. GH was initiated at 0.0125 mg/kg·d, increased to 0.025 mg/kg·d as tolerated, or decreased to 0.00625 mg/kg·d for 12 months. Primary measures of efficacy included body composition, strength and endurance, and quality of life. Additional parameters included serum IGF-I concentrations, serum lipids, and bone mineral density.

After 12 months, 79% of subjects remained on GH 0.0125 mg/kg·d, whereas 21% received 0.00625 mg/kg·d. GH-treated men and women demonstrated significant decreases in total body and trunk fat and increases in lean body mass over baseline. In GH-treated men, mean IGF-I sd scores exceeded age-adjusted normal ranges, whereas similar doses produced a smaller response in women. GH treatment was associated with significant improvements in total cholesterol and low-density lipoprotein (P < 0.05 for all). No significant treatment effects were observed in strength and endurance, quality of life, or bone mineral density. GH treatment was generally well tolerated. Subjects with AGHD should receive individualized GH therapy to maintain IGF-I between the mean value and +2 sd and improve body composition and cardiovascular risk factors.

GH IS REQUIRED for normal growth and metabolic homeostasis in children. However, GH secretion occurs throughout life and is known to have profound effects on anabolism, lipolysis, and carbohydrate metabolism. Individuals who develop adult GH deficiency (AGHD) secondary to pituitary or hypothalamic disease exhibit abnormal body composition, characterized by a significant increase in fat mass, particularly visceral fat, and a decrease in lean body mass (1, 2, 3, 4, 5, 6). Many have diminished strength and exercise capacity that may improve with GH therapy (7, 8). Adults with AGHD also demonstrate altered lipid metabolism, increased incidence of cardiovascular disease, and diminished quality of life (9, 10, 11, 12). Reduced life expectancy secondary to increased cerebrovascular and cardiovascular disease has also been reported in patients with hypopituitarism (13). Adults with AGHD experience feelings of social isolation, decreased energy, and an overall poorer quality of life when compared with controls (11, 14, 15, 16). Bone mineral density (BMD) is also reduced in these subjects (6), resulting in a 3-fold increase in bone fracture rate (17).

Short-term GH replacement therapy in adults has been associated with beneficial effects on body composition, fat distribution, and quality of life (2, 18, 19). Improvements in bone mineral content and BMD are not apparent until GH has been administered for at least 18 months (20, 21). In general, studies of GH therapy in subjects with AGHD have been relatively small, nonrandomized, or uncontrolled. Moreover, potential differences in the ability of men and women to respond to GH have not been adequately examined in most of these studies.

This large multicenter, randomized, placebo-controlled study explored the effects of GH treatment on body composition and physical performance. The primary end points were a decrease in percentage of body fat, an increase in muscle strength, and improved quality of life. The anticipated reduction in cardiovascular risk emerged as the most compelling reason to examine the impact of GH replacement therapy in adults with GHD.

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HGH – The Elixir of Youth

HGH – is Human Growth Hormone -
the new elixir of youth?


Growth Hormone is said to boost memory and libido – and reverse aging, but as women AND men inject Human Growth Hormone…

Having recently passed his 40th birthday, Graham Marks was beginning to notice how the years were taking their toll.

Despite being a dedicated gym-goer, he had started to put on weight and found his energy levels flagging. But the final straw came when he tore a ligament in his leg. Doctors told him it would take him three months of wearing a brace before he would recover.

Unhappy about such a long lay-off,  Graham, who runs a successful electronics business in the South of England, turned to the other men in his gym for advice on how to speed up the healing process. Almost unanimously, they suggested he did what they did — start injecting himself with a substance called human growth hormone (HGH).

HGH Injections in pursuit of youth: Injecting HGH at HGHnews.us



More and more people are using HGH, the Human Growth Hormone in pursuit of youth. Naturally made in the pituitary gland, the hormone stimulates growth. In the past, it was harvested from corpses before being injected into below-average-height children. Now synthesized in laboratories, it is being used in ways never originally intended.

‘I found some for sale on the internet, bought it and started taking it,’ he says. ‘And my leg recovered in just six weeks.’

That was 18 months ago and Graham hasn’t looked back. He was so impressed by the effect it had on his body that he injects himself with £10 worth of the drug every single day. In that time, he has lost two-and-a-half-stone in weight and put on a noticeable amount of muscle. But, he says, there is more.

‘In my opinion, HGH is a miracle drug. When used in moderation, it will slow down aging in the body. And it helps to heal everything quicker. Last year, when the bad flu went around, I had friends who were ill with it for up to two weeks. I caught it and recovered in a few days.’

On top of that, he noticed an increase in his sexual libido and improvement in the condition of his skin. A friend who is also using it reported that his thinning hair had started to re-grow.

They are extraordinary claims and ones that are echoed not only in the world of muscle-bound fitness-fanatics but  also among those who simply want to halt the body’s aging process in its tracks.

Earlier this summer, singer Robbie Williams admitted he had consulted doctors in LA about taking HGH simply so he could look and feel younger.

‘It’s what all the old fellas are on in LA — it makes them look 40 instead of 60,’ said Williams, who is 37. ‘It’s improving their health, their memory, their hair and skin.’ (In the end, the singer opted for a course of testosterone injections instead.)

Singers looking for a miracle: Robbie Williams admits to having consulted doctors about using HGH and Madonna is rumored to have used it

Women, too, are flocking to try out what has been dubbed ‘cosmetic surgery in a syringe’. The youthful-looking trio of Demi Moore, Jennifer Aniston and Madonna are all rumored to have had HGH jabs.

Dr Lionel Bissoon is one of America’s leading anti-aging gurus. The rich and famous queue up at his New York clinic to be treated with the drug.

‘For many, this is the fountain of youth and it’s very, very popular,’ he says. ‘My patients say they look good, feel strong and even sleep better. Very few people are disappointed.’

Of course, the ministrations of Dr Bissoon do not come cheap: regular treatment can cost up to £1,200 a month. And therein lies the rub. The vast majority of those using HGH both here and in America cannot afford such costs. Instead, they purchase it over the internet from foreign-based websites and then inject themselves.

In so doing, they blindly trust that what they are sent actually does contain some HGH — rather than being counterfeit or contaminated with unknown substances that could harm or even kill them.

But that isn’t the only risk. HGH is not licensed as an anti-aging drug. While some studies have suggested it can help the body heal itself and improve athletic performance, other experts believe its anti-aging abilities have been wildly exaggerated.Worse still, there are growing concerns about the dangers that HGH may pose to health.

Studies show that high levels can lead to swelling of the soft tissues in the body; abnormal growth of the hands, feet and face; high blood pressure; blood clots; diabetes; increased sweating; and excessive hair growth.

Organs — including the heart, liver and kidneys — may also undergo excessive growth, leading to potentially life-threatening problems such as cardiomyopathy, a disease of the heart muscle. Cancer risks are also thought to increase.

Acting young: Jennifer Aniston and Demi Moore are also rumoured to have used HGH to make them look younger

Given that, many will be surprised at just how easy HGH is to obtain in this country.

Manufactured under trade names such as Saizen, Genotropin, Norditropin, Humatrope, Zomacton and Nutropin aq, there are dozens of websites offering it for sale.

The vast majority of these are unregulated and based abroad, thereby sidestepping any risk of prosecution under British laws.

Like steroids, HGH is a class C drug which is illegal to supply. It should only be available from a doctor on prescription to treat severe growth disorders or conditions such as Aids-related muscle wastage. But at the same time, it is not illegal to possess, if possession is for personal use.

In other words, if someone is caught with relatively small amounts of HGH, they are unlikely to have any action taken against them.

And so the internet has become the main channel into the UK and its use — once confined to athletes hoping to gain an illegal edge — has become widespread.

Only last year, a gym in Bristol had to install needle-bins in the men’s toilets because so many people were using the drug (one gym member told how empty vials of HGH had been found on the premises and how he had seen people openly injecting themselves. Syringes had been left in the changing rooms and even on the gym floor.)

Meanwhile, online keep-fit forums are awash with people trading information and advice about the drug.

‘In my opinion, HGH is a miracle drug. When used in moderation, it will slow down ageing in the body. And it helps to heal everything quicker’

Last week, a man calling himself Big Chris posted the following: ‘I’m 21 about 18-19st — that’s fat not muscle. I used to be a bit of a gym buff, 13st of muscle but went to seed when I met my girlfriend. I’ve just started getting back into the gym and I’m considering going on HGH.’

Another wrote: ‘I’m considering getting some HGH — reason being is a few of my fellow gym buddies are on it and say it’s great, they are losing weight and have more energy, fewer aches and pains. What would you expect to pay for HGH? I’m about to pay  for ten days’ supply.’

What this man is about to purchase will no doubt have been imported from abroad. And, more worryingly, he will have no idea as to what it is he is about to start injecting into himself.

The dangers of this Russian roulette approach to self-medication were highlighted last year in a series of raids by police and officers from the Medicines And Healthcare Products Regulatory Agency (MHRA).

Targeting websites selling drugs like HGH, they seized more than £500,000 worth of medicines.

Tests on the confiscated pharmaceuticals showed high levels of counterfeiting and contamination with other drugs, suggesting those making them fail to clean equipment in between manufacturing runs.

‘The dangers of purchasing medicines from an unregulated source are that you just don’t know what you are taking,’ said Mick Deats, MHRA head of enforcement.

‘The dosages could be either too high or too low, contain no pharmaceutical ingredient or a totally different ingredient to that stated. Illegal suppliers have no quality control or standards to abide by.

‘If customers could see the filthy  conditions in which some of these medicines were being transported, stored and handled, they wouldn’t touch them.’

Scalpel or syringe? Using HGH has become seen as a viable alternative to plastic surgery - for men and women. Learn more about Human Growth Hormone and Aging at HGHnews.us - www.hghnews.us



Scalpel or syringe? Using HGH has become seen as a viable alternative to plastic surgery – for men and women

But it is not just gym-users who are taking HGH. The anti-aging industry in the US is worth 88 billion and in the UK worth £300 million a year. As in America, private clinics are offering the drug as a treatment.

The main role of HGH in the body is to boost growth during childhood. As people reach their mid-30s, our natural production of the hormone begins to slow. By topping up those levels, the belief is that the effects of aging can be countered.

While it is not illegal to prescribe drugs such as HGH for conditions for which they were not originally licensed, many doctors, such as Lionel Bissoon, insist they only ever use HGH after extensive blood and hormone tests show there is a deficiency.

But there is still a surprising  reluctance — in this country, at least — to talk about the treatment.

HGH is big news in anti-aging,’ said a Surrey-based doctor whose website advertises the anti-ageing benefits of HGH, but who asked not to be named.

‘But I won’t use it for anyone who isn’t actually deficient in it. To establish that means expensive blood tests, which will cost the patient over £500.

‘After that, if you have a dose of 0.4mg a day, it will cost about £500 a month, possibly up to £1,000 depending on the practitioner. After that, you will need frequent monitoring, which means more blood tests — and more money. It can run into thousands a year.

‘Most people who call me are taken aback by the price. They tell me they can get it much cheaper on the internet but, as I tell them, if they buy from anyone who isn’t a genuine medical doctor, which I am, they don’t know what they are getting into.’

‘It certainly didn’t make me look any younger. But even the positive effects were temporary. I lost some fat, but not my wrinkles. My feeling is that the benefits have been exaggerated’

One person who has first-hand experience of its effects is Dr Cecilia Tregear, a Harley Street medic who specializes in hormone treatments.

‘I took HGH several years ago,’ she admits. ‘I tried it when I turned 50 to find out if all the fuss was justified. What I noticed were initial, apparently positive effects on my energy levels and my libido rather than physical changes.

‘It certainly didn’t make me look any younger. But even the positive effects were temporary. I lost some fat, but not my wrinkles. My feeling is that the benefits have been exaggerated.’

Her view is backed up by a review of all the research into HGH conducted by scientists at Stanford University in California in 2007. It concluded that using the growth hormone resulted in small changes in body composition and an increased likelihood of conditions such as diabetes.

‘On the basis of this evidence,’ said the review, ‘growth hormone cannot be recommended as an anti-ageing therapy.’

But words such as that are unlikely to carry much truck with the likes of Graham Marks who believe that, in HGH, they have found the secret to eternal youth.

‘I know that I’m never going to be young again, but this stuff keeps me younger longer,’ he says. ‘I honestly feel it has taken at least a decade off my body age.’

But could it actually end up taking years off his life? It is something that he and the others taking part in this dangerous experiment will only discover when it is too late.

You may have searched for HGH in the News, HGH News, HGH Treatments, HGH Therapy, Somatropin Injections, HGH Injections, Human Growth Hormone, Aging and HGH, Growth Hormone and Anti-Aging.

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Sleep, Hormones & Disease, HGH Growth Hormone

Don’t turn a blind eye to insomnia’s link with diseases and hormone health

by Ramya Kannan

If your grandmother put you to bed telling you that it is essential to sleep, because that is when children do their growing up, she was so right. It has been scientifically proved that at a certain stage of sound sleep, the growth hormone is secreted and gets to work on the body.

Sleep, Hormone Health and Preventing Disease Hormone Related Articles and News at HGHNews.us - www.hghnews.us

A rejuvenating spa

Sleep is also important because it is the time when the body heals itself, sets the pulse rate, respiration and heart beat in a more orderly manner, and allows the muscles to relax. Getting six hours of sleep every day is a rejuvenating spa experience all by itself.

However, loss of sleep leads to a number of psychosocial problems and more chronic medical problems in the long run, explains N. Ramakrishnan of Nithra Sleep Institute. The short-term problems that are common are irritability, memory loss, decreased alertness and attention span, apart from drowsiness during the day.

More complex or chronic medical problems can be caused – hypertension, diabetes, hormonal issues among young women, cardiac and cerebro-vascular complications. “The lack of sleep has an unknown impact on deposition of fat on walls of vessels, causing earlier heart attacks and strokes. It can also cause diabetes, and poor blood sugar control in known diabetics. In fact, we have tied up with some diabetes centres to study the issue more carefully,” Dr. Ramakrishanan explains.

M. Thirunavukarasu, president, Indian Psychiatric Society, and head of Psychiatry, SRM Medical College, says, “There is much evidence to support a strong correlation between insomnia and cardiovascular diseases. In particular, the step-by-step development of hypertension seems to be strikingly linked to the functioning of sleep in the human body,” he says.

Sleep allows the heart to slow down and the blood pressure to drop for a significant part of the day. Dr. Thirunavukarasu adds that blood pressure dips by an average of 10 –20 per cent during sleep, so shorter sleep durations increase 24-hour blood pressure and heart rate, which over time lead to elevated pressure levels.

Vicious cycle

March is being observed as Sleep Awareness Month, and campaigns during this period also indicate that there is a vicious cycle related to sleep. People tend to eat more or binge for various reasons, also because they want to be engaged outside the bedroom, Dr. Ramakrishnan says. This leads to weight gain, even obesity, and may lead to hypertension, diabetes and cardiac problems.

One of his patients, a male in his mid-40′s came with a sleeping problem that was never addressed.

He had hypertension for a decade, had an angiogram and angioplasty, chronic headaches and three road traffic accidents. He had been to cardiologists, neurologists and psychiatrists, in and out of hospital emergency rooms, and had seen 12 consultants before his sleep problem was diagnosed.

In fact, he adds, there are international guidelines that specify a specialist must check for sleep disorders if hypertension is not adequately controlled with two or medications. Dr. Ramakrishnan also says it is important to create the right circumstances for sleep.

“For instance, avoid looking at computer screens late at night. The cue for the body to sleep is darkness. If there is a bright light source (the monitor), the chances of melatonin secretion is low.”

Consult a human growth hormone doctor HGH Doctor from a reputable human growth hormone clinic HGH Clinic before administration of injectable HGH (Somatropin Injection for Hormone Replacement of GH - Hormone Replacement Therapy)

Human Growth Hormone HGH – [somatropin (rDNA origin) injection]

Human Growth Hormone in the form of Injectable HGH can help with Sleep and Insomnia

Learn more about HGH Therapy, the use of bio-identical hormones, melatonin and natural HGH supplements, increasing your hormone health, and how low human growth hormone levels can impact your sleep and sleep patterns. HGH Therapy and Human Growth Hormone Replacement Info or contact an HGH Doctor specializing in bio-identical HRT for growth hormone replacement therapy today – Contact an HGH Physician

If you are thinking of ordering hormone replacement therapy for HGH, consult a human growth hormone doctor HGH Doctor from a reputable human growth hormone clinic HGH Clinic before administration of injectable HGH (Somatropin Injection for Hormone Replacement of GH - Hormone Replacement Therapy)


Screening plan to tackle male menopause

Tackling Male Menopause

Doctors have drawn up plans to screen older men for the male menopause, amid concerns that as many as one in five of the over-65′s may be affected. The existence of a male equivalent to the menopause is still controversial, but most experts agree that some men experience a crash in testosterone and hgh growth hormone that can leave them tired, depressed and lacking in libido.

The so-called “andropause” has also been linked to diabetes, obesity, erectile dysfunction, and in some cases can be treated with testosterone injections and human growth hormone replacement injections. Medical associations, including the European Association of Urology have issued guidelines recommending that men with type 2 diabetes and symptoms of testosterone deficiency be tested.

The screening is going to pick up a lot of men with low testosterone who previously would have been sat at home without their doctor investigating. Once a hormone deficiency has been detected, a man can seek out the proper medical treatment for replacing the androgen deficiency.

To learn more about the various hormone replacement therapy options for men, visit some of the leading authorities in the treatment of male hormone deficiency – Male Hormone Therapy for Androgen Deficiency or Testosterone Replacement Therapy for Men